Preclinical and clinical investigation of intratumoral chemotherapy pharmacokinetics in DIPG using gemcitabine

BACKGROUND: Hundreds of systemic chemotherapy trials in diffuse intrinsic pontine glioma (DIPG) have not improved survival, potentially due to lack of intratumoral penetration, which has not previously been assessed in humans. METHODS: We used gemcitabine as a model agent to assess DIPG intratumoral...

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Publicat a:Neurooncol Adv
Autors principals: Green, Adam L, Flannery, Patrick, Hankinson, Todd C, O’Neill, Brent, Amani, Vladimir, DeSisto, John, Knox, Aaron, Chatwin, Hannah, Lemma, Rakeb, Hoffman, Lindsey M, Mulcahy Levy, Jean, Raybin, Jennifer, Hemenway, Molly, Gilani, Ahmed, Koschmann, Carl, Dahl, Nathan, Handler, Michael, Pierce, Angela, Venkataraman, Sujatha, Foreman, Nicholas, Vibhakar, Rajeev, Wempe, Michael F, Dorris, Kathleen
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2020
Matèries:
Basic and Translational Investigations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7212907/
https://ncbi.nlm.nih.gov/pubmed/32642682
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/noajnl/vdaa021
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