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PHRM-04. COMPARISON OF PHARMACOKINETIC PARAMETERS BETWEEN NON-HUMAN PRIMATES AND HUMAN PATIENTS
INTRODUCTION: Chemotherapeutic agents are evaluated in at least two animal species prior to evaluation in humans. In children with CNS tumors, the plasma and CSF pharmacokinetics of these agents are derived from models like non-human primates (NHP) to predict CNS penetration. However, the extent to...
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| Publicado en: | Neuro Oncol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6012663/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.582 |
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