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PHRM-04. COMPARISON OF PHARMACOKINETIC PARAMETERS BETWEEN NON-HUMAN PRIMATES AND HUMAN PATIENTS

INTRODUCTION: Chemotherapeutic agents are evaluated in at least two animal species prior to evaluation in humans. In children with CNS tumors, the plasma and CSF pharmacokinetics of these agents are derived from models like non-human primates (NHP) to predict CNS penetration. However, the extent to...

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Pubblicato in:Neuro Oncol
Autori principali: Baratz, Ethan, McCully, Cynthia, Shih, Joanna, Warren, Katherine
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012663/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.582
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