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PHRM-04. COMPARISON OF PHARMACOKINETIC PARAMETERS BETWEEN NON-HUMAN PRIMATES AND HUMAN PATIENTS
INTRODUCTION: Chemotherapeutic agents are evaluated in at least two animal species prior to evaluation in humans. In children with CNS tumors, the plasma and CSF pharmacokinetics of these agents are derived from models like non-human primates (NHP) to predict CNS penetration. However, the extent to...
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| 出版年: | Neuro Oncol |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Oxford University Press
2018
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6012663/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.582 |
| タグ: |
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