CSF1R-dependent myeloid cells are required for NK‑mediated control of metastasis

Myeloid leukocytes are essentially involved in both tumor progression and control. We show that neo-adjuvant treatment of mice with an inhibitor of CSF1 receptor (CSF1R), a drug that is used to deplete tumor-associated macrophages, unexpectedly promoted metastasis. CSF1R blockade indirectly diminish...

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Bibliografski detalji
Izdano u:JCI Insight
Glavni autori: Beffinger, Michal, de Lara, Paulino Tallón, Tugues, Sònia, Vermeer, Marijne, Montagnolo, Yannick, Ohs, Isabel, Cecconi, Virginia, Lucchiari, Giulia, Gagliardi, Aron, Misljencevic, Nikola, Sutton, James, Spörri, Roman, Becher, Burkhard, Gupta, Anurag, van den Broek, Maries
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2018
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012573/
https://ncbi.nlm.nih.gov/pubmed/29769439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97792
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