CD39(+)PD-1(+)CD8(+) T cells mediate metastatic dormancy in breast cancer

Some breast tumors metastasize aggressively whereas others remain dormant for years. The mechanism governing metastatic dormancy remains largely unknown. Through high-parametric single-cell mapping in mice, we identify a discrete population of CD39(+)PD-1(+)CD8(+) T cells in primary tumors and in do...

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Publicado no:Nat Commun
Main Authors: Tallón de Lara, Paulino, Castañón, Héctor, Vermeer, Marijne, Núñez, Nicolás, Silina, Karina, Sobottka, Bettina, Urdinez, Joaquín, Cecconi, Virginia, Yagita, Hideo, Movahedian Attar, Farkhondeh, Hiltbrunner, Stefanie, Glarner, Isabelle, Moch, Holger, Tugues, Sònia, Becher, Burkhard, van den Broek, Maries
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2021
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7859213/
https://ncbi.nlm.nih.gov/pubmed/33536445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-021-21045-2
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