CSF1R-dependent myeloid cells are required for NK‑mediated control of metastasis

Myeloid leukocytes are essentially involved in both tumor progression and control. We show that neo-adjuvant treatment of mice with an inhibitor of CSF1 receptor (CSF1R), a drug that is used to deplete tumor-associated macrophages, unexpectedly promoted metastasis. CSF1R blockade indirectly diminish...

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Détails bibliographiques
Publié dans:JCI Insight
Auteurs principaux: Beffinger, Michal, de Lara, Paulino Tallón, Tugues, Sònia, Vermeer, Marijne, Montagnolo, Yannick, Ohs, Isabel, Cecconi, Virginia, Lucchiari, Giulia, Gagliardi, Aron, Misljencevic, Nikola, Sutton, James, Spörri, Roman, Becher, Burkhard, Gupta, Anurag, van den Broek, Maries
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012573/
https://ncbi.nlm.nih.gov/pubmed/29769439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97792
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