CSF1R-dependent myeloid cells are required for NK‑mediated control of metastasis

Myeloid leukocytes are essentially involved in both tumor progression and control. We show that neo-adjuvant treatment of mice with an inhibitor of CSF1 receptor (CSF1R), a drug that is used to deplete tumor-associated macrophages, unexpectedly promoted metastasis. CSF1R blockade indirectly diminish...

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Pubblicato in:JCI Insight
Autori principali: Beffinger, Michal, de Lara, Paulino Tallón, Tugues, Sònia, Vermeer, Marijne, Montagnolo, Yannick, Ohs, Isabel, Cecconi, Virginia, Lucchiari, Giulia, Gagliardi, Aron, Misljencevic, Nikola, Sutton, James, Spörri, Roman, Becher, Burkhard, Gupta, Anurag, van den Broek, Maries
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012573/
https://ncbi.nlm.nih.gov/pubmed/29769439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97792
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