CSF1R-dependent myeloid cells are required for NK‑mediated control of metastasis

Myeloid leukocytes are essentially involved in both tumor progression and control. We show that neo-adjuvant treatment of mice with an inhibitor of CSF1 receptor (CSF1R), a drug that is used to deplete tumor-associated macrophages, unexpectedly promoted metastasis. CSF1R blockade indirectly diminish...

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Udgivet i:JCI Insight
Main Authors: Beffinger, Michal, de Lara, Paulino Tallón, Tugues, Sònia, Vermeer, Marijne, Montagnolo, Yannick, Ohs, Isabel, Cecconi, Virginia, Lucchiari, Giulia, Gagliardi, Aron, Misljencevic, Nikola, Sutton, James, Spörri, Roman, Becher, Burkhard, Gupta, Anurag, van den Broek, Maries
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2018
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012573/
https://ncbi.nlm.nih.gov/pubmed/29769439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.97792
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