DIPG-05. PRECLINICAL EFFICACY OF MELK INHIBITION IN DIFFUSE INTRINSIC PONTINE GLIOMA

Maternal embryonic leucine zipper kinase (MELK) is a highly overexpressed kinase in diffuse intrinsic pontine glioma (DIPG). Inhibition of MELK by the small molecule OTSSP167 effectively reduces proliferation and induces cell death in primary DIPG cell lines at low nanomolar concentrations. RNA sequ...

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Dettagli Bibliografici
Pubblicato in:Neuro Oncol
Autori principali: Meel, Michaël, de Gooijer, Mark, Navarro, Miriam Guillén, Waranecki, Piotr, Breur, Marjolein, Buil, Levi, Wedekind, Laurine, Twisk, Jos, Koster, Jan, Hashizume, Rintaro, Raabe, Eric, Carcaboso, Ángel Montero, Bugiani, Marianna, van Tellingen, Olaf, van Vuurden, Dannis, Kaspers, Gertjan, Hulleman, Esther
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
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Abstracts
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012060/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.099
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