DIPG-05. PRECLINICAL EFFICACY OF MELK INHIBITION IN DIFFUSE INTRINSIC PONTINE GLIOMA

Maternal embryonic leucine zipper kinase (MELK) is a highly overexpressed kinase in diffuse intrinsic pontine glioma (DIPG). Inhibition of MELK by the small molecule OTSSP167 effectively reduces proliferation and induces cell death in primary DIPG cell lines at low nanomolar concentrations. RNA sequ...

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Bibliografski detalji
Izdano u:Neuro Oncol
Glavni autori: Meel, Michaël, de Gooijer, Mark, Navarro, Miriam Guillén, Waranecki, Piotr, Breur, Marjolein, Buil, Levi, Wedekind, Laurine, Twisk, Jos, Koster, Jan, Hashizume, Rintaro, Raabe, Eric, Carcaboso, Ángel Montero, Bugiani, Marianna, van Tellingen, Olaf, van Vuurden, Dannis, Kaspers, Gertjan, Hulleman, Esther
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2018
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Abstracts
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012060/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.099
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