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DIPG-05. PRECLINICAL EFFICACY OF MELK INHIBITION IN DIFFUSE INTRINSIC PONTINE GLIOMA
Maternal embryonic leucine zipper kinase (MELK) is a highly overexpressed kinase in diffuse intrinsic pontine glioma (DIPG). Inhibition of MELK by the small molecule OTSSP167 effectively reduces proliferation and induces cell death in primary DIPG cell lines at low nanomolar concentrations. RNA sequ...
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| Izdano u: | Neuro Oncol |
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| Glavni autori: | , , , , , , , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Oxford University Press
2018
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6012060/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.099 |
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