DIPG-05. PRECLINICAL EFFICACY OF MELK INHIBITION IN DIFFUSE INTRINSIC PONTINE GLIOMA

Maternal embryonic leucine zipper kinase (MELK) is a highly overexpressed kinase in diffuse intrinsic pontine glioma (DIPG). Inhibition of MELK by the small molecule OTSSP167 effectively reduces proliferation and induces cell death in primary DIPG cell lines at low nanomolar concentrations. RNA sequ...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Neuro Oncol
Main Authors: Meel, Michaël, de Gooijer, Mark, Navarro, Miriam Guillén, Waranecki, Piotr, Breur, Marjolein, Buil, Levi, Wedekind, Laurine, Twisk, Jos, Koster, Jan, Hashizume, Rintaro, Raabe, Eric, Carcaboso, Ángel Montero, Bugiani, Marianna, van Tellingen, Olaf, van Vuurden, Dannis, Kaspers, Gertjan, Hulleman, Esther
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Abstracts
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6012060/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.099
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker