DIPG-15. EFFECTIVE PRECLINICAL TREATMENT OF DIFFUSE INTRINSIC PONTINE GLIOMA BY MELK INHIBITION

Maternal embryonic leucine zipper kinase (MELK) is the second highest expressed kinase in diffuse intrinsic pontine glioma (DIPG). Inhibition of MELK by the small molecule OTSSP167 effectively reduces proliferation and induces cell death in primary DIPG cell lines at low nanomolar concentrations. RN...

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Detaylı Bibliyografya
Yayımlandı:Neuro Oncol
Asıl Yazarlar: Meel, Michaël H, Guillén-Navarro, Miriam, de Gooijer, Mark C, Waranecki, Piotr, Buijl, Levi CM, van Tellingen, Olaf, van Vuurden, Dannis G, Kaspers, Gertjan JL, Hulleman, Esther
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Oxford University Press 2017
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Abstracts
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474996/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.030
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