Φορτώνει......
ATRT-02. THE AURORA KINASE A (AURKA) INHIBITOR ALISERTIB ACTS SYNERGISTICALLY WITH A POLO-LIKE KINASE 4 (PLK4) INHIBITOR TO TARGET ATYPICAL TERATOID / RHABDOID TUMOR (AT/RT) CELLS
BACKGROUND: Previously, we observed that CRISPR/Cas9-induced mutations in the PLK4 gene, a critical regulator of centriole duplication, significantly impaired proliferation and survival of AT/RT cells. We established that PLK4 is overexpressed in AT/RT and inhibiting PLK4 resulted in impaired prolif...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | Neuro Oncol |
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| Κύριοι συγγραφείς: | , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
Oxford University Press
2018
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6011979/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.001 |
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