ATRT-02. THE AURORA KINASE A (AURKA) INHIBITOR ALISERTIB ACTS SYNERGISTICALLY WITH A POLO-LIKE KINASE 4 (PLK4) INHIBITOR TO TARGET ATYPICAL TERATOID / RHABDOID TUMOR (AT/RT) CELLS

BACKGROUND: Previously, we observed that CRISPR/Cas9-induced mutations in the PLK4 gene, a critical regulator of centriole duplication, significantly impaired proliferation and survival of AT/RT cells. We established that PLK4 is overexpressed in AT/RT and inhibiting PLK4 resulted in impaired prolif...

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Publicado en:Neuro Oncol
Main Authors: Bailey, Anders, Suri, Amreena, Dyer, Connor, Horn, Clara, Tomita, Tadanori, Sredni, Simone
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6011979/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.001
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