ATRT-04. A FUNCTIONAL SCREENING OF THE KINOME IDENTIFIES THE POLO-LIKE KINASE 4 (PLK4) AS A POTENTIAL THERAPEUTIC TARGET FOR ATYPICAL TERATOID/RHABDOID TUMORS (AT/RT), AND POSSIBLY, OTHER EMBRYONAL TUMORS OF THE BRAIN

BACKGROUND: Atypical teratoid / rhabdoid tumors (AT/RT) are deadly embryonal tumors of the brain. With poor survival and modest response to current therapies, more effective and less toxic treatments are needed. We hypothesized that a systematic screening of the kinome will reveal kinases that drive...

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Veröffentlicht in:Neuro Oncol
Hauptverfasser: Sredni, Simone, Suzuki, Mario, Yang, Jian-Ping, Topczewski, Jacek, de Andrade, Alexandre, Bailey, Anders, Gross, Jeffrey, Kondo, Akihide, Piper, David, Tomita, Tadanori
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5474968/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox083.003
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