DIPG-55. TARGETING SENESCENT CELLS WITH ABT-263 ENHANCES CELL DEATH INDUCED BY BMI1 INHIBITION AND IONIZING RADIATION IN DIPG

Ionizing Radiation (IR) is a key treatment modality for DIPG, but it provides only temporary relief as the tumor cells develop resistance to radiation. Recently, we and others have shown that inhibition of BMI1 either alone or in combination with radiation attenuates DIPG cell proliferation in vitro...

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Pubblicato in:Neuro Oncol
Autori principali: Balakrishnan, Ilango, Madhavan, Krishna, Pierce, Angela, Dahl, Nathan, Lemma, Rakeb, Fosmire, Susan, Wang, Dong, Prince, Eric, Alimova, Irina, Hashizume, Rintaro, Huellman, Esther, Hawkins, Cynthia, Carcaboso, Angel Montero, Gupta, Nalin, Monje, Michelle, Jones, Keneth, Green, Adam, Foreman, Nicholas, Vibhakar, Rajeev, Venkataraman, Sujatha
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
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Abstracts
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6011937/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy059.148
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