Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants

BACKGROUND: Recent advances in clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) genome editing have led to the use of long single-stranded DNA (lssDNA) molecules for generating conditional mutations. However, there is still limited available data...

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Gepubliceerd in:BMC Biol
Hoofdauteurs: Codner, Gemma F., Mianné, Joffrey, Caulder, Adam, Loeffler, Jorik, Fell, Rachel, King, Ruairidh, Allan, Alasdair J., Mackenzie, Matthew, Pike, Fran J., McCabe, Christopher V., Christou, Skevoulla, Joynson, Sam, Hutchison, Marie, Stewart, Michelle E., Kumar, Saumya, Simon, Michelle M., Agius, Loranne, Anstee, Quentin M., Volynski, Kirill E., Kullmann, Dimitri M., Wells, Sara, Teboul, Lydia
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: BioMed Central 2018
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6011369/
https://ncbi.nlm.nih.gov/pubmed/29925374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-018-0530-7
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