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Correction of the auditory phenotype in C57BL/6N mice via CRISPR/Cas9-mediated homology directed repair
BACKGROUND: Nuclease-based technologies have been developed that enable targeting of specific DNA sequences directly in the zygote. These approaches provide an opportunity to modify the genomes of inbred mice, and allow the removal of strain-specific mutations that confound phenotypic assessment. On...
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| Publicado no: | Genome Med |
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| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4753642/ https://ncbi.nlm.nih.gov/pubmed/26876963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-016-0273-4 |
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