Correction of the auditory phenotype in C57BL/6N mice via CRISPR/Cas9-mediated homology directed repair

BACKGROUND: Nuclease-based technologies have been developed that enable targeting of specific DNA sequences directly in the zygote. These approaches provide an opportunity to modify the genomes of inbred mice, and allow the removal of strain-specific mutations that confound phenotypic assessment. On...

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Библиографические подробности
Опубликовано в: :Genome Med
Главные авторы: Mianné, Joffrey, Chessum, Lauren, Kumar, Saumya, Aguilar, Carlos, Codner, Gemma, Hutchison, Marie, Parker, Andrew, Mallon, Ann-Marie, Wells, Sara, Simon, Michelle M., Teboul, Lydia, Brown, Steve D. M., Bowl, Michael R.
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2016
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4753642/
https://ncbi.nlm.nih.gov/pubmed/26876963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13073-016-0273-4
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