Application of long single-stranded DNA donors in genome editing: generation and validation of mouse mutants

BACKGROUND: Recent advances in clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) genome editing have led to the use of long single-stranded DNA (lssDNA) molecules for generating conditional mutations. However, there is still limited available data...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:BMC Biol
Main Authors: Codner, Gemma F., Mianné, Joffrey, Caulder, Adam, Loeffler, Jorik, Fell, Rachel, King, Ruairidh, Allan, Alasdair J., Mackenzie, Matthew, Pike, Fran J., McCabe, Christopher V., Christou, Skevoulla, Joynson, Sam, Hutchison, Marie, Stewart, Michelle E., Kumar, Saumya, Simon, Michelle M., Agius, Loranne, Anstee, Quentin M., Volynski, Kirill E., Kullmann, Dimitri M., Wells, Sara, Teboul, Lydia
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2018
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6011369/
https://ncbi.nlm.nih.gov/pubmed/29925374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12915-018-0530-7
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