Identification of new allosteric sites and modulators of AChE through computational and experimental tools

Allosteric sites on proteins are targeted for designing more selective inhibitors of enzyme activity and to discover new functions. Acetylcholinesterase (AChE), which is most widely known for the hydrolysis of the neurotransmitter acetylcholine, has a peripheral allosteric subsite responsible for am...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Roca, Carlos, Requena, Carlos, Sebastián-Pérez, Víctor, Malhotra, Sony, Radoux, Chris, Pérez, Concepción, Martinez, Ana, Antonio Páez, Juan, Blundell, Tom L., Campillo, Nuria E.
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6010107/
https://ncbi.nlm.nih.gov/pubmed/29873262
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1476502
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