Cysteine Protease-Mediated Autocleavage of Clostridium difficile Toxins Regulates Their Proinflammatory Activity

BACKGROUND & AIMS: Clostridium difficile toxin A (TcdA) and C difficile toxin toxin B (TcdB), the major virulence factors of the bacterium, cause intestinal tissue damage and inflammation. Although the 2 toxins are homologous and share a similar domain structure, TcdA is generally more inflammat...

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Veröffentlicht in:Cell Mol Gastroenterol Hepatol
Hauptverfasser: Zhang, Yongrong, Li, Shan, Yang, Zhiyong, Shi, Lianfa, Yu, Hua, Salerno-Goncalves, Rosangela, Saint Fleur, Ashley, Feng, Hanping
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2018
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009800/
https://ncbi.nlm.nih.gov/pubmed/29930981
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2018.01.022
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