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Cytotoxicity of Clostridium difficile toxin B does not require cysteine protease-mediated autocleavage and release of the glucosyltransferase domain into the host cell cytosol
Clostridium difficile virulence requires secretion of two exotoxins, TcdA and TcdB. The precise mechanism of toxin uptake and delivery is undefined, but current models predict that the cysteine protease domain (CPD) mediated autocleavage and release of glucosyltransferase domain (GTD) is crucial for...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3742912/ https://ncbi.nlm.nih.gov/pubmed/23620115 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/2049-632X.12016 |
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