PRMT5-mediated arginine methylation of TDP1 for the repair of topoisomerase I covalent complexes

Human tyrosyl-DNA phosphodiesterases (TDP) hydrolyze the phosphodiester bond between DNA and the catalytic tyrosine of Top1 to excise topoisomerase I cleavage complexes (Top1cc) that are trapped by camptothecin (CPT) and by genotoxic DNA alterations. Here we show that the protein arginine methyltran...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Nucleic Acids Res
Autors principals: Rehman, Ishita, Basu, Suparna M, Das, Subhendu K, Bhattacharjee, Sangheeta, Ghosh, Arijit, Pommier, Yves, Das, Benu Brata
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2018
Matèries:
Genome Integrity, Repair and Replication
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009676/
https://ncbi.nlm.nih.gov/pubmed/29718323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky291
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars