Poly(ADP-ribose) polymers regulate DNA topoisomerase I (Top1) nuclear dynamics and camptothecin sensitivity in living cells

Topoisomerase 1 (Top1) is essential for removing the DNA supercoiling generated during replication and transcription. Anticancer drugs like camptothecin (CPT) and its clinical derivatives exert their cytotoxicity by reversibly trapping Top1 in covalent complexes on the DNA (Top1cc). Poly(ADP-ribose)...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Das, Subhendu K., Rehman, Ishita, Ghosh, Arijit, Sengupta, Souvik, Majumdar, Papiya, Jana, Biman, Das, Benu Brata
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2016
Assuntos:
Nucleic Acid Enzymes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5041477/
https://ncbi.nlm.nih.gov/pubmed/27466387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw665
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