Neutral Porphyrin Derivative Exerts Anticancer Activity by Targeting Cellular Topoisomerase I (Top1) and Promotes Apoptotic Cell Death without Stabilizing Top1-DNA Cleavage Complexes

[Image: see text] Camptothecin (CPT) selectively traps topoisomerase 1-DNA cleavable complexes (Top1cc) to promote anticancer activity. Here, we report the design and synthesis of a new class of neutral porphyrin derivative 5,10-bis(4-carboxyphenyl)-15, 20-bis(4-dimethylaminophenyl)porphyrin (compou...

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Detalhes bibliográficos
Publicado no:J Med Chem
Main Authors: Das, Subhendu K., Ghosh, Arijit, Paul Chowdhuri, Srijita, Halder, Nyancy, Rehman, Ishita, Sengupta, Souvik, Sahoo, Krushna Chandra, Rath, Harapriya, Das, Benu Brata
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5808360/
https://ncbi.nlm.nih.gov/pubmed/29290109
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01297
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