PRMT5-mediated arginine methylation of TDP1 for the repair of topoisomerase I covalent complexes

Human tyrosyl-DNA phosphodiesterases (TDP) hydrolyze the phosphodiester bond between DNA and the catalytic tyrosine of Top1 to excise topoisomerase I cleavage complexes (Top1cc) that are trapped by camptothecin (CPT) and by genotoxic DNA alterations. Here we show that the protein arginine methyltran...

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Detalhes bibliográficos
Publicado no:Nucleic Acids Res
Main Authors: Rehman, Ishita, Basu, Suparna M, Das, Subhendu K, Bhattacharjee, Sangheeta, Ghosh, Arijit, Pommier, Yves, Das, Benu Brata
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Genome Integrity, Repair and Replication
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6009676/
https://ncbi.nlm.nih.gov/pubmed/29718323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky291
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