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Cystamine and Disulfiram Inhibit Human Transglutaminase 2 via an Oxidative Mechanism

The catalytic activity of transglutaminase 2 (TG2), a ubiquitously expressed mammalian enzyme, is regulated by multiple post-translational mechanisms. Because elevated activity of TG2 in the extracellular matrix is associated with organ-specific diseases such as celiac disease and renal fibrosis, th...

詳細記述

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書誌詳細
出版年:Biochemistry
主要な著者: Palanski, Brad A., Khosla, Chaitan
フォーマット: Artigo
言語:Inglês
出版事項: 2018
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6008213/
https://ncbi.nlm.nih.gov/pubmed/29570977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00204
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