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An Unprecedented Dual Antagonist and Agonist of Human Transglutaminase 2
Transglutaminase 2 (TG2) is a ubiquitously expressed, Ca(2+)-activated extracellular enzyme in mammals that is maintained in a catalytically dormant state by multiple mechanisms. Although its precise physiological role in the extracellular matrix remains unclear, aberrantly up-regulated TG2 activity...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4607565/ https://ncbi.nlm.nih.gov/pubmed/26004580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2015.05.006 |
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