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Cystamine and Disulfiram Inhibit Human Transglutaminase 2 via an Oxidative Mechanism
The catalytic activity of transglutaminase 2 (TG2), a ubiquitously expressed mammalian enzyme, is regulated by multiple post-translational mechanisms. Because elevated activity of TG2 in the extracellular matrix is associated with organ-specific diseases such as celiac disease and renal fibrosis, th...
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| Udgivet i: | Biochemistry |
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| Main Authors: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6008213/ https://ncbi.nlm.nih.gov/pubmed/29570977 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.8b00204 |
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