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Discovery of Potent and Specific Dihydroisoxazole Inhibitors of Human Transglutaminase 2

[Image: see text] Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme that catalyzes the posttranslational modification of glutamine residues on protein or peptide substrates. A growing body of literature has implicated aberrantly regulated activity of TG2 in the pathogenesis of various huma...

詳細記述

保存先:
書誌詳細
出版年:J Med Chem
主要な著者: Klöck, Cornelius, Herrera, Zachary, Albertelli, Megan, Khosla, Chaitan
フォーマット: Artigo
言語:Inglês
出版事項: American Chemical Society 2014
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4234452/
https://ncbi.nlm.nih.gov/pubmed/25333388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm501145a
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