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Novel VDR antagonists based on the GW0742 scaffold
The vitamin D receptor is a nuclear hormone receptor that regulates cell proliferation, cell differentiation and calcium homeostasis. The receptor is endogenously activated by 1,25-dihydroxyvitamin D(3), which induces transcription of VDR targets genes regulated by coactivator binding. VDR antagonis...
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| Udgivet i: | Bioorg Med Chem Lett |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6008168/ https://ncbi.nlm.nih.gov/pubmed/29287957 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.12.041 |
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