Gene Therapy for Osteoarthritis: Pharmacokinetics of Intra-Articular Self-Complementary Adeno-Associated Virus Interleukin-1 Receptor Antagonist Delivery in an Equine Model

Toward the treatment of osteoarthritis (OA), the authors have been investigating self-complementary adeno-associated virus (scAAV) for intra-articular delivery of therapeutic gene products. As OA frequently affects weight-bearing joints, pharmacokinetic studies of scAAV gene delivery were performed...

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Bibliografski detalji
Izdano u:Hum Gene Ther Clin Dev
Glavni autori: Watson Levings, Rachael S., Broome, Ted A., Smith, Andrew D., Rice, Brett L., Gibbs, Eric P., Myara, David A., Hyddmark, E. Viktoria, Nasri, Elham, Zarezadeh, Ali, Levings, Padraic P., Lu, Yuan, White, Margaret E., Dacanay, E. Anthony, Foremny, Gregory B., Evans, Christopher H., Morton, Alison J., Winter, Mathew, Dark, Michael J., Nickerson, David M., Colahan, Patrick T., Ghivizzani, Steven C.
Format: Artigo
Jezik:Inglês
Izdano: Mary Ann Liebert, Inc. 2018
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007808/
https://ncbi.nlm.nih.gov/pubmed/29869540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/humc.2017.142
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