Self-Complementary Adeno-Associated Virus–Mediated Interleukin-1 Receptor Antagonist Gene Delivery for the Treatment of Osteoarthritis: Test of Efficacy in an Equine Model

The authors are investigating self-complementary adeno-associated virus (scAAV) as a vector for intra-articular gene-delivery of interleukin-1 receptor antagonist (IL-1Ra), and its therapeutic capacity in the treatment of osteoarthritis (OA). To model gene transfer on a scale proportional to the hum...

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Foilsithe in:Hum Gene Ther Clin Dev
Main Authors: Watson Levings, Rachael S., Smith, Andrew D., Broome, Ted A., Rice, Brett L., Gibbs, Eric P., Myara, David A., Hyddmark, E. Viktoria, Nasri, Elham, Zarezadeh, Ali, Levings, Padraic P., Lu, Yuan, White, Margaret E., Dacanay, E. Anthony, Foremny, Gregory B., Evans, Christopher H., Morton, Alison J., Winter, Mathew, Dark, Michael J., Nickerson, David M., Colahan, Patrick T., Ghivizzani, Steven C.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Mary Ann Liebert, Inc. 2018
Ábhair:
Research Articles
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007806/
https://ncbi.nlm.nih.gov/pubmed/29869535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/humc.2017.143
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