Intra-articular gene delivery and expression of interleukin-1Ra mediated by self-complementary adeno-associated virus

BACKGROUND: The adeno-associated virus (AAV) has many safety features that favor its use in the treatment of arthritic conditions; however, the conventional, single-stranded vector is inefficient for gene delivery to fibroblastic cells that primarily populate articular tissues. This has been attribu...

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Main Authors: Kay, Jesse D., Gouze, Elvire, Oligino, Thomas J., Gouze, Jean-Noel, Watson, Rachael S., Levings, Padraic P., Bush, Marsha L., Dacanay, Anthony, Nickerson, David M., Robbins, Paul D., Evans, Christopher H., Ghivizzani, Steven C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2876984/
https://ncbi.nlm.nih.gov/pubmed/19384892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jgm.1334
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