Gene delivery of TGF-β1 induces arthrofibrosis and chondrometaplasia of synovium in vivo

To understand the cellular and molecular events contributing to arthrofibrosis, we used an adenovirus to deliver and overexpress transforming growth factor-beta 1 (TGF-β1) cDNA (Ad.TGF-β1) in the knee joints of immunocompromised rats. Following delivery, animals were killed periodically, and joint t...

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Autori principali: Watson, Rachael S, Gouze, Elvire, Levings, Padraic P, Bush, Marsha L, Kay, Jesse D, Jorgensen, Marda S, Dacanay, E Anthony, Reith, John W, Wright, Thomas W, Ghivizzani, Steven C
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724510/
https://ncbi.nlm.nih.gov/pubmed/20697373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/labinvest.2010.145
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