Gene Therapy for Osteoarthritis: Pharmacokinetics of Intra-Articular Self-Complementary Adeno-Associated Virus Interleukin-1 Receptor Antagonist Delivery in an Equine Model

Toward the treatment of osteoarthritis (OA), the authors have been investigating self-complementary adeno-associated virus (scAAV) for intra-articular delivery of therapeutic gene products. As OA frequently affects weight-bearing joints, pharmacokinetic studies of scAAV gene delivery were performed...

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Detalhes bibliográficos
Publicado no:Hum Gene Ther Clin Dev
Main Authors: Watson Levings, Rachael S., Broome, Ted A., Smith, Andrew D., Rice, Brett L., Gibbs, Eric P., Myara, David A., Hyddmark, E. Viktoria, Nasri, Elham, Zarezadeh, Ali, Levings, Padraic P., Lu, Yuan, White, Margaret E., Dacanay, E. Anthony, Foremny, Gregory B., Evans, Christopher H., Morton, Alison J., Winter, Mathew, Dark, Michael J., Nickerson, David M., Colahan, Patrick T., Ghivizzani, Steven C.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007808/
https://ncbi.nlm.nih.gov/pubmed/29869540
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/humc.2017.142
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