Discovery and optimization of cardenolides inhibiting HSF1 activation in human colon HCT-116 cancer cells

Combinational anticancer therapy demonstrates increased efficiency, as it targets different cell-survival mechanisms and allows the decrease of drug dosages that are often toxic to normal cells. Inhibitors of the heat shock response (HSR) are known to reduce the efficiency of proteostasis mechanisms...

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Vydáno v:Oncotarget
Hlavní autoři: Nikotina, Alina D., Koludarova, Lidia, Komarova, Elena Y., Mikhaylova, Elena R., Aksenov, Nikolay D., Suezov, Roman, Kartzev, Viktor G., Margulis, Boris A., Guzhova, Irina V.
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2018
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007471/
https://ncbi.nlm.nih.gov/pubmed/29930764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25545
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