Discovery and optimization of cardenolides inhibiting HSF1 activation in human colon HCT-116 cancer cells

Combinational anticancer therapy demonstrates increased efficiency, as it targets different cell-survival mechanisms and allows the decrease of drug dosages that are often toxic to normal cells. Inhibitors of the heat shock response (HSR) are known to reduce the efficiency of proteostasis mechanisms...

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Dettagli Bibliografici
Pubblicato in:Oncotarget
Autori principali: Nikotina, Alina D., Koludarova, Lidia, Komarova, Elena Y., Mikhaylova, Elena R., Aksenov, Nikolay D., Suezov, Roman, Kartzev, Viktor G., Margulis, Boris A., Guzhova, Irina V.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2018
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Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6007471/
https://ncbi.nlm.nih.gov/pubmed/29930764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.25545
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