Sensitizing tumor cells to conventional drugs: HSP70 chaperone inhibitors, their selection and application in cancer models

Hsp70 chaperone controls proteostasis and anti-stress responses in rapidly renewing cancer cells, making it an important target for therapeutic compounds. To date several Hsp70 inhibitors are presented with remarkable anticancer activity, however their clinical application is limited by the high tox...

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Pubblicato in:Cell Death Dis
Autori principali: Lazarev, Vladimir F., Sverchinsky, Dmitry V., Mikhaylova, Elena R., Semenyuk, Pavel I., Komarova, Elena Y., Niskanen, Sergey A., Nikotina, Alina D., Burakov, Anton V., Kartsev, Viktor G., Guzhova, Irina V., Margulis, Boris A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2018
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833849/
https://ncbi.nlm.nih.gov/pubmed/29348557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0160-y
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