Sensitizing tumor cells to conventional drugs: HSP70 chaperone inhibitors, their selection and application in cancer models

Hsp70 chaperone controls proteostasis and anti-stress responses in rapidly renewing cancer cells, making it an important target for therapeutic compounds. To date several Hsp70 inhibitors are presented with remarkable anticancer activity, however their clinical application is limited by the high tox...

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Publicat a:Cell Death Dis
Autors principals: Lazarev, Vladimir F., Sverchinsky, Dmitry V., Mikhaylova, Elena R., Semenyuk, Pavel I., Komarova, Elena Y., Niskanen, Sergey A., Nikotina, Alina D., Burakov, Anton V., Kartsev, Viktor G., Guzhova, Irina V., Margulis, Boris A.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5833849/
https://ncbi.nlm.nih.gov/pubmed/29348557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-017-0160-y
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