Etoposide-Induced Apoptosis in Cancer Cells Can Be Reinforced by an Uncoupled Link between Hsp70 and Caspase-3

The Hsp70 chaperone binds and inhibits proteins implicated in apoptotic signaling including Caspase-3. Induction of apoptosis is an important mechanism of anti-cancer drugs, therefore Hsp70 can act as a protective system in tumor cells against therapeutic agents. In this study we present an assessme...

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Publicado no:Int J Mol Sci
Main Authors: Sverchinsky, Dmitry V., Nikotina, Alina D., Komarova, Elena Y., Mikhaylova, Elena R., Aksenov, Nikolay D., Lazarev, Vladimir F., Mitkevich, Vladimir A., Suezov, Roman, Druzhilovskiy, Dmitry S., Poroikov, Vladimir V., Margulis, Boris A., Guzhova, Irina V.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6163214/
https://ncbi.nlm.nih.gov/pubmed/30149619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms19092519
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