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Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions
Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure in many developed countries. Mitochondrial oxidative stress is considered to be the predominant cellular event in APAP-induced liver injury. Accordingly, N-acetyl cysteine, a known scavenger of reactive oxygen spe...
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| Publicado no: | Redox Biol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6006912/ https://ncbi.nlm.nih.gov/pubmed/29753208 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2018.04.019 |
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