Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions

Acetaminophen (APAP) overdose is the leading cause of drug-induced acute liver failure in many developed countries. Mitochondrial oxidative stress is considered to be the predominant cellular event in APAP-induced liver injury. Accordingly, N-acetyl cysteine, a known scavenger of reactive oxygen spe...

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Bibliographic Details
Published in:Redox Biol
Main Authors: Yan, Mingzhu, Huo, Yazhen, Yin, Shutao, Hu, Hongbo
Format: Artigo
Language:Inglês
Published: Elsevier 2018
Subjects:
Review Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006912/
https://ncbi.nlm.nih.gov/pubmed/29753208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2018.04.019
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