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Protective role of p53 in acetaminophen hepatotoxicity

p53 is a tumor suppressor with a pro-death role in many conditions. However, in some contexts, evidence supports a pro-survival function. p53 has been shown to be activated in acetaminophen (APAP) toxicity but the impact of this on toxicity is uncertain. In the present study, we have found that p53...

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Detalhes bibliográficos
Publicado no:Free Radic Biol Med
Main Authors: Huo, Yazhen, Yin, Shutao, Yan, Mingzhu, Win, Sanda, Than, Tin Aung, Aghajan, Mariam, Hu, Hongbo, Kaplowitz, Neil
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396540/
https://ncbi.nlm.nih.gov/pubmed/28196650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.02.028
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