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Protective role of p53 in acetaminophen hepatotoxicity

p53 is a tumor suppressor with a pro-death role in many conditions. However, in some contexts, evidence supports a pro-survival function. p53 has been shown to be activated in acetaminophen (APAP) toxicity but the impact of this on toxicity is uncertain. In the present study, we have found that p53...

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Dettagli Bibliografici
Pubblicato in:Free Radic Biol Med
Autori principali: Huo, Yazhen, Yin, Shutao, Yan, Mingzhu, Win, Sanda, Than, Tin Aung, Aghajan, Mariam, Hu, Hongbo, Kaplowitz, Neil
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2017
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5396540/
https://ncbi.nlm.nih.gov/pubmed/28196650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2017.02.028
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