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Direct Protection Against Acetaminophen Hepatotoxicity by Propylthiouracil
Hepatotoxicity caused by acetaminophen can be prevented by enzyme-catalyzed conjugation of its reactive metabolite with glutathione (GSH). Since we have shown in previous studies that 6-N-propyl-2-thiouracil (PTU) can substitute for GSH as a substrate for the GSH S-transferases, we examined the poss...
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| Publicado no: | J Clin Invest |
|---|---|
| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Clinical Investigation
1981
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC370618/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7204554/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI110084 |
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