MECHANISM OF PROTECTION BY METALLOTHIONEIN AGAINST ACETAMINOPHEN HEPATOTOXICITY

Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver failure in the US. Metallothionein (MT) expression attenuates APAP-induced liver injury. However, the mechanism of this protection remains incompletely understood. To address this issue, C57BL/6 mice were treated with 100...

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Bibliographic Details
Main Authors: Saito, Chieko, Yan, Hui-Min, Artigues, Antonio, Villar, Maria T., Farhood, Anwar, Jaeschke, Hartmut
Format: Artigo
Language:Inglês
Published: 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2789886/
https://ncbi.nlm.nih.gov/pubmed/19835899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2009.10.006
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