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NOVEL MECHANISMS OF PROTECTION AGAINST ACETAMINOPHEN HEPATOTOXICITY IN MICE BY GLUTATHIONE AND N-ACETYLCYSTEINE

Acetaminophen (APAP) overdose is a major cause of acute liver failure. The glutathione (GSH) precursor N-acetylcysteine (NAC) is used to treat patients with APAP overdose for up to 48 h. Although it is well established that early treatment with NAC can improve the scavenging of the reactive metaboli...

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Bibliografiske detaljer
Main Authors: Saito, Chieko, Zwingmann, Claudia, Jaeschke, Hartmut
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2977522/
https://ncbi.nlm.nih.gov/pubmed/19821517
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.23267
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