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Effect of excipients on acetaminophen metabolism and its implications for prevention of liver injury
Acetaminophen poisoning is the most frequent cause of acute hepatic failure in the US. Toxicity requires reductive metabolism of acetaminophen, primarily via CYP2E1. Liquid acetaminophen preparations contain propylene glycol, a common excipient that has been shown to reduce hepatocellular injury in...
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| Publicat a: | J Clin Pharmacol |
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| Autors principals: | , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2013
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4383763/ https://ncbi.nlm.nih.gov/pubmed/23436315 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.24 |
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