Increased oxidative stress mediates the antitumor effect of PARP inhibition in ovarian cancer

PARP inhibitors have been widely tested in clinical trials, especially for the treatment of breast cancer and ovarian cancer, and were shown to be highly successful. Because PARP primarily functions in sensing and repairing DNA strand breaks, the therapeutic effect of PARP inhibition is generally be...

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Udgivet i:Redox Biol
Main Authors: Hou, Dong, Liu, Zhaojian, Xu, Xiuhua, Liu, Qiao, Zhang, Xiyu, Kong, Beihua, Wei, Jian-Jun, Gong, Yaoqin, Shao, Changshun
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6006521/
https://ncbi.nlm.nih.gov/pubmed/29684820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2018.03.016
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