A tool compound targeting the core binding factor Runt domain to disrupt binding to CBFβ

The core binding factor (CBF) gene RUNX1 is a target of chromosomal translocations in leukemia, including the t(8;21) in acute myeloid leukemia (AML). Normal CBF function is essential for the activity of AML1-ETO, product of the t(8;21), and for the survival of several leukemias lacking RUNX1 mutati...

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Bibliografske podrobnosti
izdano v:Leuk Lymphoma
Main Authors: Oo, Zaw Min, Illendula, Anuradha, Grembecka, Jolanta, Schmidt, Charles, Zhou, Yunpeng, Esain, Virginie, Kwan, Wanda, Frost, Isaura, North, Trista E., Rajewski, Roger A., Speck, Nancy A., Bushweller, John H.
Format: Artigo
Jezik:Inglês
Izdano: 2017
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6005736/
https://ncbi.nlm.nih.gov/pubmed/29249175
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/10428194.2017.1410882
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