Central Nervous System Regulation of Embryonic HSPC Production via Stress-Responsive Glucocorticoid Receptor Signaling

Hematopoietic stem and progenitor cell (HSPC) specification is regulated by numerous defined factors acting locally within the hemogenic niche, however, it is unclear whether production can adapt to fluctuating systemic needs. Here, we show the central nervous system controls embryonic HSPC producti...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Kwan, Wanda, Cortes, Mauricio, Frost, Isaura, Esain, Virginie, Theodore, Lindsay N., Liu, Sarah Y., Budrow, Nadine, Goessling, Wolfram, North, Trista E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5181112/
https://ncbi.nlm.nih.gov/pubmed/27424782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.06.004
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