Cannabinoid Receptor-2 Regulates Embryonic Hematopoietic Stem Cell Development via Prostaglandin E2 and P-Selectin Activity

Cannabinoids (CB) modulate adult hematopoietic stem and progenitor cell (HSPCs) function, however, impact on the production, expansion, or migration of embryonic HSCs is currently uncharacterized. Here, using chemical and genetic approaches targeting CB-signaling in zebrafish, we show that CB recept...

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Detalhes bibliográficos
Publicado no:Stem Cells
Main Authors: Esain, Virginie, Kwan, Wanda, Carroll, Kelli J., Cortes, Mauricio, Liu, Sarah Y., Frechette, Gregory M., Sheward, Lea M. V., Nissim, Sahar, Goessling, Wolfram, North, Trista E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4781665/
https://ncbi.nlm.nih.gov/pubmed/25931248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/stem.2044
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