Evi1 regulates Notch activation to induce zebrafish hematopoietic stem cell emergence

During development, hematopoietic stem cells (HSCs) emerge from aortic endothelial cells (ECs) through an intermediate stage called hemogenic endothelium by a process known as endothelial‐to‐hematopoietic transition (EHT). While Notch signaling, including its upstream regulator Vegf, is known to reg...

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Veröffentlicht in:EMBO J
Hauptverfasser: Konantz, Martina, Alghisi, Elisa, Müller, Joëlle S, Lenard, Anna, Esain, Virginie, Carroll, Kelli J, Kanz, Lothar, North, Trista E, Lengerke, Claudia
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2016
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5090218/
https://ncbi.nlm.nih.gov/pubmed/27638855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201593454
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